Major Histocompatibility
It is a type of glycoprotein that acts as a receptor on the cell surface. It exists in the form of a set of genes in chromosomes. In humans, the Major Histocompatibility chromosome no. six genes are also found, also called human leukocyte antigen. But in the mouse chromosome No. 17 it is found in the main function of Major Histocompatibility to bind to small peptides of antigens and expose them to the cell surface. .
1. Help with Cell Collaboration
2. Identification of Non-Cells
3.Orthopedic Assistance
4. An important role in both cell protection and human immunity
Types of Major Histocompatibility
Major Histocompatibility molecules are divided into three types.
Major Histocompatibility-1 and Major Histocompatibility-2 molecules are commonly referred to as MHC molecules and Major Histocompatibility-3 is neither old nor antiquated.
1. Major Histocompatibility-1
is found in the surface of the nucleated cell, having two components in their structure. The first part is made up of free glycoproteins. This is called the alpha chain and three parts of this alpha chain are Alpha-1, Alpha-2, Alpha-3, these three parts extracellular light chain protein non-covalent bond. The Major Histocompatibility-1 molecule is bound to a Tc-cell with an alpha-3 domain.
MHC-1 + Tc + CD 8
Major Histocompatability glycoproteins are present in antigen-presenting cells, as they are found on the surface of B-cells and dendritic cells. These Major Histo Compatibility molecules deliver antigen peptides to the cell.
2. Major Histocompatibility-2
Subunit Two in the Major Histocompatibility-2 Building where. The alpha chain divided into two domains is Alpha-1, Alpha-2 similarly beta is divided into two domains. A Beeta-1, Beeta-2 chain is connected to an alpha series by a non-binding bond. Gene formation HLA-DQ, HLA-DP, HLA-DR for MHC-2. The Alpha series is 33 K/D and the beta chain is 28 K/D.A is found between Alpha-1 and Beeta-1, which is activated to capture foreign antigens.
Major Histocopatibility Property
1. Major Histocompatibility genes are polygenic, all genes combine to form MHC proteins.
2. The smell is polymorphic, Their structure varies greatly. Because it is made up of different types of amino acids.
3. The current genes of Major Histocompatibility are extremely artificial
4. Cytokines increase odor expression
